Anti-peptide antibody blocks peptide binding to MHC class I molecules in the endoplasmic reticulum.

Endoplasmic Reticulum Binding to MHC Class I Molecules in the Anti-Peptide Antibody Blocks Peptide

Redox-regulated export of the major histocompatibility complex class I-peptide complexes from the endoplasmic reticulum.

In contrast to the fairly well-characterized mechanism of assembly of MHC class I-peptide complexes, the disassembly mechanism by which peptide-loaded MHC class I molecules are released from the peptide-loading complex and exit the endoplasmic reticulum (ER) is poorly understood. Optimal peptide binding by MHC class I molecules is assumed to be sufficient for triggering exit of peptide-filled M...

Forcing tumor cells to present their own tumor antigens to the immune system: a necessary design for an efficient tumor immunotherapy.

The general principle for tumor cells to escape from immune surveillance is to prevent tumor antigens from being recognized by the immune system. Many methods have been developed to increase the immunogenecity of the tumor cells. The most efficient methods are able to force tumor cells to present their own tumor antigens to the immune system. Stimulating Th cells by converting tumor cells into ...

Phosphorylated peptides can be transported by TAP molecules, presented by class I MHC molecules, and recognized by phosphopeptide-specific CTL.

CTL recognize short peptide fragments presented by class I MHC molecules. In this study, we examined the effect of phosphorylation on TAP transport, binding to class I MHC molecules, and recognition by CTL of peptide fragments from known phosphorylated oncogene proteins or virus phosphoproteins. We show that phosphopeptides can be efficiently transported from the cytosol to the endoplasmic reti...

پیشرفت های جدید در شناخت اسپوندیلوآرتروپاتی ها

In last few years, numerous observations and studies on pathogenesis of spondyloarthropathies have been published and an animal model which confirms the associations of new information is now available. Bacteria which are responsible for reactive arthritis all can remain in the cells for long time. Molecules of class I MHC are able to present the intracellular peptides to immune system. B27 mol...